interleukin-1α
Mouse mature interleukin-1α (IL-1α) is a 17 kDa protein cleaved from a leaderless 31 kDa precursor. In mice, IL-1α is produced primarily by lymphocytes and macrophages. The IL-1α is encoded by a gene family composed of IL-1α, IL-1β, and IL-1Rα in a chromosome.
They are produced by alternative splicing of RNA. When stimulated with bacterial endotoxin and other pathogens, mRNA of IL-1α is present within 15 minutes. IL-1α plays an active role in signal transduction through its receptor, IL-1R which is shared with other IL-1 molecules. Recombinant IL-1α generated in E. coli has similar biological functions in response to infectious assaults.
The recombinant IL-1α generated in E. coli is nonglycosylated and is used as antigen to immunize mice.
IL-1α
The specifications of the Mouse IL-1α ELISA Test Kit are as follows:
Format: 96-well strip plate
Assay range: 10-640 pg/ml
Sensitivity: 5 pg/ml
Total Assay Time: 3 hours and 45 minutes
Sample Size: 100 µl/well
Sample types: Serum, plasma and Cell Culture Supernatant
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