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 HOME > Cytokine Assays > Human |
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Human IL-1 Beta |
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코 드 |
: 2110 |
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단 위 |
: 1 kit |
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공 급 원 |
: Bioo |
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가 격 |
: 문의 |
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Human interleukin 1β
Human interleukin 1β (IL-1β) is a 17 kDa protein which is produced by various cells. IL-1β has multiple functions including local inflammation.
Following bacterial or immunoglobulin ligation of monocyte/macrophage CD14 (the LPS receptor) 17 or CD64 (the IgG receptor), IL-1β can be released into a local environment. Within this environment, IL-1β impacts a number of cells. facilitating mononuclear infiltration into an area of early inflammation. IL-1β also induces expression of itself in newly arriving monocytes. In terms of other pro-inflammatory molecules, IL-1β apparently is needed for the efficient production of IFN-γ. On resident NK cells, IL-1β apparently works in conjunction with macrophage-derived IL-12 to induce IFN-γ secretion, resulting in an IFN-γ induced activation of macrophages. Finally, IL-1β also induces the expression of MMPs from resident fibroblasts.
This can have at least two effects: first extracellular matrix degradation can facilitate monocyte migration, and second, MMPs are known to degrade IL-1β, thus down-modulating the local inflammatory response initiated by IL-1. |
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interleukin beta
The specifications of the MaxSignal™ Human IL-1β ELISA Test Kit are as follows:
Format: 96-well strip plate
Assay range: 1.2-76.8 pg/ml
Sensitivity: 0.6 pg/ml
Total Assay Time: 3 hour and 45 minutes
Sample Size: 100 µl/well
Sample types: Serum, plasma and Cell Culture Supernatant
Wavelength for plate reading: A450 nm
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Product Code |
Unit |
Price |
Availability |
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2110 |
1.2-76.8 pg/ml |
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