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 HOME > Cytokine Assays > Human |
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Human IL-2 |
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코 드 |
: 2104 |
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단 위 |
: 1 kit |
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공 급 원 |
: Bioo |
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가 격 |
: 문의 |
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IL-2
Mature human interleukin 2 (IL-2) is a 15-18 kDa glycoprotein of 133 amino acids after cleavage of a signal peptide of 20 amino acids. It contains three cysteine residues, two of which form a disulfide bond that is required for biological activity. It is a lymphokine synthesized and secreted primarily by T helper lymphocytes that have been activated by stimulation with certain mitogens or by interaction of the T cell receptor complex with antigen/MHC complexes on the surfaces of antigen-presenting cells.
The response of T helper cells to activation is induction of the expression of IL-2 and receptors for IL-2 and, subsequently, clonal expansion of antigen-specific T cells. At this level IL-2 is an autocrine factor, driving the expansion of the antigen-specific cells. IL-2 also acts as a paracrine factor, influencing the activity of other cells, both within the immune system and outside of it. B cells and natural killer (NK) cells respond, when properly activated, to IL-2. The so-called lymphocyte activated killer, or LAK cells, appear to be derived from NK cells under the influence of IL-2. Murine IL-2 is approximately 63% identical to human IL-2, but contains a unique stretch of repeated glutamine residues. There is marked species cross-reactivity as human IL-2 has been found to be active on murine cell lines.
Cells known to produce IL-2 include thymocytes, gamma delta T-cells, B-cells, CD4+ and CD8+ T-cells, and neurons plus astrocytes. |
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Human IL-2
The specifications of the Human IL-2 ELISA Test Kit are as follows:
Format: 96-well strip plate
Assay range: 40-2500 pg/ml
Sensitivity: 20 pg/ml
Total Assay Time: 3 hour and 45 minutes
Sample Size: 100 µl/well
Sample types: Serum, plasma and Cell Culture Supernatant
Wavelength for plate reading: A450 nm
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Product Code |
Unit |
Price |
Availability |
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2104 |
40-2500 pg/ml |
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